Development of retinoic acid syndrome during leukopenia
نویسندگان
چکیده
منابع مشابه
Retinoic acid signalling during development.
Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. The distribution and levels of RA in embryonic tissues are tightly controlled by regulated synthesis through the action of specific retinol and retinaldehyde dehydrogenases and by degradation via sp...
متن کاملRetinoic Acid Syndrome: A Case Report and Review
Background: The treatment of acute promyelocy!c leukemia with all-trans-re!noic acid (ATRA) some!mes results in a syndrome characterized by fever, respiratory distress, weight gain, pleural or pericardial effusion, and pulmonary infiltrates. We report the major clinical and radiologic features of ATRA syndrome. Materials and Methods: In the past, occasional case reports and literature pertainin...
متن کاملFunction of retinoic acid receptors during embryonic development
Retinoids, the active metabolites of vitamin A, regulate complex gene networks involved in vertebrate morphogenesis, growth, cellular differentiation and homeostasis. Studies performed in vitro, using either acellular systems or transfected cells, have shown that retinoid actions are mediated through heterodimers between the RAR and RXR nuclear receptors. However, in vitro studies indicate what...
متن کاملMesenchyme-mediated effects of retinoic acid during rat intestinal development.
In previous experiments we showed that intestinal development was dependent upon epithelial-mesenchymal cell interactions. The aim of this study was to investigate the possible role of retinoic acid (RA), a morphogenetic and differentiating agent, on the gut epithelial-mesenchymal unit. For this purpose we first analyzed the effects of a physiological dose of RA on 14-day fetal rat intestine us...
متن کاملRetinoic acid syndrome: a review.
The retinoic acid syndrome (RAS) is an unpredictable but frequent complication which may develop after administration of all-trans retinoic acid (ATRA) most commonly in patients with acute promyelocytic leukaemia (APL). In this review, we describe the incidence, predictive factors, clinical course, outcome and treatment of RAS in patients with APL treated with ATRA. The incidence of RAS in pati...
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ژورنال
عنوان ژورنال: International Cancer Conference Journal
سال: 2011
ISSN: 2192-3183
DOI: 10.1007/s13691-011-0006-x